Aspartame-Induced Headache

Aspartame-induced apoptosis in PC12 cells.

Aspartame is an artificial sweetner added to many low-calorie foods. The safety of aspartame remains controversial even though there are many studies on its risks. In this study, to understand the physiological effects of trace amounts of artificial sweetners on cells, the effects of aspartame on apoptosis were investigated using a PC12 cell system. In addition, the mechanism of apoptosis induc...

Neurobiochemical alterations induced by the artificial sweetener aspartame (NutraSweet).

The dipeptide aspartame (NutraSweet) is a newly approved and widely used artificial sweetener in foods and beverages. Consumption of aspartame (ASM) has been reported to be responsible for neurologic and behavioral disturbances in sensitive individuals. Unfasted male CD-1 mice were dosed orally with 13, 130, or 650 mg/kg ASM in corn oil, while control animals received corn oil alone. Three hour...

Aspartame m a review

Aspartame (APM), a newly available synthetic sweetener approximately 180-200 times sweeter than sucrose, was approved for marketing by the FDA in 1981 following several years of scientific review. It is available in the United States for use as a sweetener in breakfast cereals, powdered beverages, gelatins, puddings, fillings, whipped toppings, chewing gum, soft drinks and as a table-top sweete...

Aspartame: review of safety.

Over 20 years have elapsed since aspartame was approved by regulatory agencies as a sweetener and flavor enhancer. The safety of aspartame and its metabolic constituents was established through extensive toxicology studies in laboratory animals, using much greater doses than people could possibly consume. Its safety was further confirmed through studies in several human subpopulations, includin...

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